It also shows CaMKII
is key in the formation of long-term memory.
Lastly, we observed higher expression of NR2B and CaMKII
in PC12 cells treated with corticosterone than in the control group (P<0.01, n=8) (Figure 9).
Abbreviations: AMPA-R: AMPA-type glutamate receptor; APP: amyloid precursor protein; CaMKII
: Ca2D/calmodulin-dependent protein kinase II; DISC1: Disrupted-in-Schizophrenia 1; ENU: N-ethyl-N-nitrosourea; EPSP: excitatory postsynaptic potential; ERP: event-related potential; IPSP: inhibitory postsynaptic potential; NMDA-R: N-methyl D-aspartate receptor; P30: postnatal day 30; P60: postnatal day 60; PAK: p21-activated kinase; PCP: phencyclidine; PFC: prefrontal cortex; PPI: prepulse inhibition; PSD: postsynaptic density; shRNA: short hairpin RNA; SZ: schizophrenia; VAMP2: vesicle associated membrane protein 2.
Calcium/calmodulin-dependent protein kinase II (CaMKII
) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.
Lv et al., "LncRNA TINCR attenuates cardiac hypertrophy by epigenetically silencing CaMKII
," Oncotarget, vol.
Interestingly, a number of studies have indicated that CaMKII
enhances mitochondrial dysfunction, ROS formation, and apoptosis , eventually causing cardiomyocyte death both following hyperglycemia [64, 65] and oxidative stress conditions [43, 45, 66].
For example, the autophosphorylation of CAMKII
is required in the CA1 but not in the dentate gyrus [47, 48].
They demonstrated that simvastatin causes an influx of calcium ions through the TRPV1-TRPA1 (transient receptor potential ankyrin 1) pathway, which then causes activation of CaMKII
([Ca.sup.2+]/calmodulin-dependent protein kinase II).
in myocardial hypertrophy and heart failure.
Some of the mechanisms related to neuropathic pain involve CaMKII
and PKC, which may be relevant to the pain of SCD.
Molecular interaction and functional regulation of C1C-3 by [Ca.sup.2+]/calmodulin-dependent protein kinase II (CaMKII
) in human malignant glioma.