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References in periodicals archive ?
When patients were on a calcineurin inhibitor, the risk of keratinocyte carcinomas increased incrementally by 2.6 events per 100 patients per year of follow-up, and the SCC risk increased by 1.7 events per 100 patients per year of follow-up.
Therapy may include topical and intralesional corticosteroids, topical calcineurin inhibitors, destructive treatment methods, or sometimes even immunosuppressants (30).
Curtis, "Hypertensinogenic mechanism of the calcineurin inhibitors," Current Hypertension Reports, vol.
All patients received initial immunosuppres-sive therapy with prednisolone (P), antimetabolites (mycophenolatemofetil-(MMF), azathioprine-(AZA)) combined with calcineurin inhibitors (CNI; cyclosporin A-CyA/, tacrolimus-Tac), interleukin-2 receptor antagonists (IL-2ra) or mechanistic target of rapamycin (mTOR) inhibitors (sirolimus(SRL)/ everolimus (EVL)).
The calcineurin inhibitors (CNIs) [6] tacrolimus (TAC) and cyclosporine A (CsA) are effective immunosuppressive agents for renal transplantation but require careful management to avoid toxicity.
A study showed that renal transplant recipients (RTRs) without calcineurin inhibitors have significantly lower numbers of CECs than their matched counterparts who received cyclosporine.12 It also reported a significant relationship between cyclosporine -but not tacrolimus - trough blood levels.
Report of the Topical Calcineurin Inhibitor Task Force of the American College of Allergy, Asthma and Immunology and the American Academy of Allergy, Asthma and Immunology.
Since an earlier investigation had suggested that treatment with a calcineurin inhibitor could improve cognitive functioning in AD mice, researchers observed what happened to calcium levels in brain cells when mice with plaques were given the calcineurin inhibitor.
The results were consistent with calcineurin inhibitor toxicity.
Voclosporin, a calcineurin inhibitor (CNI) with clinical data in over 2,400 patients across indications, is an immunosuppressant with a synergistic and dual mechanism of action.
"In a no-data situation such as this, I'll probably try to see if use a few times a week or in a mix/match between corticosteroids, a topical calcineurin inhibitor, and crisaborole will provide decent long-term disease control," Dr.
Andersson et al., "The effect of everolimus initiation and calcineurin inhibitor elimination on cardiac allograft vasculopathy in de novo recipients: one-year results of a Scandinavian randomized trial," American Journal of Transplantation, vol.