There are several calcium-based phosphate binder
products on the market, such as calcium acetate, calcium carbonate, and calcium citrate, which come in a variety of formulations.
Avoid calcium-based phosphate binders
in patients with known vascular calcifications.
Effects of sevelamer and calcium-based phosphate binders
on mortality in hemodialysis patients.
Studies in the dialysis population also report that sevelamer use results in less hypercalcemia, attenuation of arterial calcification, lower incidence of coronary artery calcification, decreased mortality, and reduced hospitalization compared to calcium-based phosphate binders
(Block et al.
The three- year trial involving more than 2,100 patients compared the difference in mortality and morbidity outcomes for patients receiving Renagel (sevelamer hydrochloride) with those using calcium-based phosphate binders
ATLANTA -- Calcium-based phosphate binders
, which are widely used to manage hyperphosphatemia in dialysis patients, appear to be an important contributor to the extraordinarily high rate of cardiovascular mortality that is seen in this population.
Calcium-based phosphate binders
emerged as alternatives to aluminum salts.
KDOQI recommends that calcium-based phosphate binders
be used for initial phosphate binder therapy for patients with Stage 3 and 4 CKD, and as an option for individuals receiving dialysis (National Kidney Foundation, 2003).
Guideline 5 suggests limiting the recommended calcium load from calcium-based phosphate binders
Calcium intake should be limited to about 1,500 to 2,000 mg/day, including calcium from dietary intake, calcium in the dialysate bath, and calcium from calcium-based phosphate binders