Impact of calreticulin
mutations on clinical and hematological phenotype and outcome in essential thrombocythemia.
is the dominant prophagocytic signal on multiple human cancers and is counterbalanced by CD47.
It has been established that in some patients with MPNs, mutation of calreticulin
(EA Pharma) have revealed a mechanism in which an analogue (ER-464195-01) of Eisai's in-house discovered E6007 inhibits integrin activation by dissociating interaction between calreticulin
(CRT) and integrin alpha 4 (ITGA4), suppressing adhesion and infiltration of leukocytes overall.
(CALR) is a major regulator of [Ca.sup.2+] levels in the endoplasmic reticulum (ER) and shows elevated expression in the SCN according to RNA in situ hybridization results.
Macrophages eat cancer cells using their own calreticulin
as a guide: roles of TLR and Btk.
Lower panel, colocalization of Nesprin2 detected by mAb K81-116-6 with ER marker calreticulin
in HaCaT cells.
Ghiringhelli et al., "Calreticulin
exposure dictates the immunogenicity of cancer cell death," Nature Medicine, vol.
Michels et al., "Calreticulin
expression: interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer," OncoImmunology, vol.
Zhao et al., "Hepatitis B virus-induced calreticulin
protein is involved in IFN resistance," The Journal of Immunology, vol.
Her initial evaluation was negative for BCR-ABL PCR testing, Janus kinase-2, calreticulin
, and MPL mutations.
CUGBP1 binds to the 5'-UTR of p21 and increases translation of p21 by competing with calreticulin
. In senescent cells, increased phosphorylation of CUGBP1 promotes binding to p21 mRNA.