Candida antarctica lipase B
has been used for by the synthesis of the serotonin reuptake inhibitor (S)-(+)-cericlamine .
The enzymatic synthesis of favor esters by transesterification from vinyl esters and alcohols catalysed by free Candida antarctica lipase B
in ionic liquids has been studied by de los Rios et al.
Kinetic resolution of (R/S)-propranolol (l-isopropylamino-3-(1-naphtoxy)-2-propanolol) catalyzed by immobilized preparations of Candida antarctica lipase B (CAL-B)".
2010 Engineering of Candida antarctica lipase B for hydrolysis of bulky carboxylic acid esters.
Yoo, "Stabilization of Candida antarctica Lipase B
in hydrophilic organic solvent by rational design of hydrogen bond," Biotechnology and Bioprocess Engineering, vol.
Loos, "Surface modification of macroporous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) resins for improved Candida antarctica lipase B
immobilization," Reactive and Functional Polymers, vol.
In this study, immobilized Candida antarctica lipase B was used to catalyze formation of liquid wax esters, such as adipate esters, via a solvent-free process.
Immobilized enzymes of Candida antarctica lipase B adsorbed on a macroporous resin (Novozym 435) and Rhizomucor miehei lipase adsorbed on an anion exchange resin (Lipozyme RM IM) were purchased from the Novozymes Company (Bagsvaerd DK, Denmark).
As part of our ongoing research, we are interested in screening more variety of alkenes with phenylacetic acid as an oxygen carrier and Novozym 435--an immobilised Candida antarctica lipase B
as a biocatalyst for the epoxidation process.