CARD

(redirected from Caspase Recruitment Domain)
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AcronymDefinition
CARDCardinal
CARDCenter for Agricultural and Rural Development
CARDCenter for Animal Resources and Development (Japan: Kumamoto University)
CARDCaspase Recruitment Domain
CARDCenter for Anxiety and Related Disorders (Boston University)
CARDCenter for Autism and Related Disabilities
CARDCampaign against Racial Discrimination (1964-1967; UK)
CARDCollaborating Agencies Responding to Disasters (California)
CARDCandidate Access Router Discovery
CARDCandidate Access Router Discovery (IANA)
CARDCaspase Recruitment Domain-Containing Protein
CARDCaspase Activation and Recruitment Domain
CARDCenter for Autism and Related Disorders, Inc.
CARDCost Analysis Requirements Document
CARDCitizens Against Radioactive Dumping
CARDContact-Based Architecture for Resource Discovery
CARDCivil Aviation Research and Development
CARDCenter for Agricultural Research and Development (various countries)
CARDComputerized Anthropometric Research and Design
CARDCasinos Austria Research & Development
CARDCitizens Advocating Responsible Development
CARDConsolidated Admissions and Reporting Directive
CARDCatalog of Approved Requirements Documents
CARDCardiac Automatic Resuscitative Device (cardiology)
CARDComputer Aided Remote Driving
CARDConceptual and Reasoning Difficulties
CARDCenter for Aquaculture Research and Development (Sarasota, Florida)
CARDCost Analysis Requirement Description
CARDCompressed Alternate Reality Data (Phantasy Star gaming)
CARDCooperative Agricultural and Rural Development Bank (India)
CARDConventional Armaments Review Document
CARDChannel Allocation and Routing Data
CARDConstellation Architecture Requirements Document (NASA)
CARDComputer-Aided Real-time Design
CARDCommunicators for Agricultural and Rural Development (Philippines)
CARDCarrot Association for Research and Development
CARDCoastal and Arctic Research Division
CARDCorrective Action, Repair & Diagnosis
CARDCommunauté d'Agglomération de la Région Dieppoise (French: Agglomeration Community of the Dieppe Region; Dieppe, France)
CARDCommunity Action and Research for Development (India)
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References in periodicals archive ?
IL-1[beta]: interleukin-1[beta]; IL-18: interleukin-18; IL- 17: interleukin-17; NLRP3: NOD-like receptor pyrin domain-containing 3; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; BBB: blood-brain barrier; GM-CSF: granulocyte-macrophage colony-stimulating factor.
ASC recruits procaspase-1 through its C-terminal caspase recruitment domain (CARD) and interacts with NLRP3 via its pyrin domain (PYD), serving as a bridge between these two molecules.
CML = [N.sup.[epsilon]] (carboxymethyl)lysine; DAMPs = damage-associated molecular patterns; eATP = extracellular ATP; ER = endoplasmic reticulum; FFAs = free fatty acids; IL-1[beta] = interleukin-1 [beta]; LDLs = low density lipoprotein; MVs = microvesicles; NADPH ox = NADPH oxidase; NF-[kappa]B = nuclear factor-[kappa]B; NLRP3 = nucleotide-binding and oligomerization domain (NOD), leucine-rich repeat and pyrin domain containing 3; PR[2X.sub.7] = purinergic receptor [2X.sub.7]; PYCARD = the PYD- CARD adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain; RAGE = receptor for advanced glycation end products; ROS = reactive oxygen species; TLR = toll-like receptor; TNF-[alpha] = tumor necrosis factor-[alpha].
ASC (apoptosis-associated speck-like protein containing a CARD), characterized as the central structure of inflammasome, contains a pyrin domain (PYD) and a caspase recruitment domain to link pattern recognition receptors (PRRs) with procaspase 1.
After interaction with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), the activated NLRP3 can recruit caspase-1 precursors and form a protein complex "inflammasome." Activated NLRP3 inflammasome, in the form of caspase-1 shear body (p20), cleaves the precursor of IL-1[beta] to form mature IL-1[beta].
After formation and activation, the NLRP3 inflammasome associates with the adaptor protein apoptosis speck-like protein containing a caspase recruitment domain (ASC) via its pyrin domain.
AMs were treated with LPS and adenosine triphosphate (ATP); caspase-1-dependent cell death was evaluated using flow cytometry; the apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) pyroptosomes were examined by immunofluorescence.
Danger-associated molecular patterns (DAMPs), for example, ATP, cholesterol crystals, urate crystals, and ceramide, promote formation of the inflammasome, which is a multimeric protein complex consisting of Nod-like receptor family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and procaspase1 [7-10].
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