CTSK

(redirected from Cathepsin K)
Also found in: Wikipedia.
AcronymDefinition
CTSKCathepsin K
CTSKCountersink
Copyright 1988-2018 AcronymFinder.com, All rights reserved.
References in periodicals archive ?
MIV-711 is a potent and selective inhibitor of cathepsin K, the principal protease involved in breaking down collagen in bone and cartilage.
Previous studies in animal models show that Cathepsin K (CTSK) is involved in autoimmune and inflammatory diseases by regulating the Toll-like receptor 9 (TLR9) signalling (Asagiri et al., 2008).
O'Donoghue, a cardiovascular medicine specialist at Brigham and Women's Hospital, noted in her presentation that "preclinical data suggested that inhibition of cathepsin K may reduce atherosclerosis progression and promote plaque stability."
The levels of serum tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP) and cathepsin K were determined by those corresponding reagent kits.
In a study performed by Zheng et al, (23) cathepsin K showed positivity in 3 of 12 cases (25%) of clear cell sarcoma (one showed focal positivity).
Osteoclasts produce cathepsin K, which is released during bone resorption and degrades collagen.
Researchers at the Georgia Institute of Technology have detected cathepsin K using a technique called gelatin zymography.
The effects of MIV-711 on these biomarkers indicate robust engagement of MIV-711 with its biological target, cathepsin K, throughout the duration of treatment.
Cathepsin K, an enzyme expressed by osteoclasts and synovial fibroblasts that plays an important role in normal skeletal physiology and in the development of RA (Salminen-Mankonen et al.
Cathepsin K, a cysteine protease enzyme, is the most abundantly synthesized protein of the resorbing osteoclast and plays a role in the degradation of organic matrix in the bone, noted Dr.
Cathepsin K, a cysteine protease enzyme, is the most abundantly synthesized protein of the resorbing osteoclast, and plays an important role in the degradation of the organic matrix of bone.