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Cells subjected to 8% strain significantly upregulated Col I and Cbfa1. Cells that underwent strain had significantly greater gene expression, with or without dex, for all markers of gene expression.
Cbfa1 is a key element in the physiological osteoblastic differentiation.
To confirm the differentiation of human PDCs into a P-MSC-related osteoblast phenotype at the molecular level, we monitored the expression of human ALP, BSP, CBFA1, Col-1, OCN, and VdR mRNAs at the first and second weeks through qRT-PCR by using human-specific primers.
Cleidocranial dyplasia (CCD) is a rare skeletal disorder caused by a defect in the CBFA1 gene on chromosome 6p21.
Role of Cbfa1 in osteoblast differentiation and function.
siRNA that targets the hypoxia pathway turns on the osteogenic protein expression via the hypoxia-inducible factor 1 (HIF 1) and siRNA that targets the bone differentiation pathway turns on the core binding factor alpha 1 (Cbfa1) pathway to activate expression of bone differentiation proteins.
Intermittent traction stretch promotes the osteoblastic differentiation of bone mesenchymal stem cells by the ERK1/2-activated Cbfa1 pathway.
Nomura et al., "Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts," Cell, vol.
No differences regarding the gene expression of BGLAP (osteocalcin) and RUNX (cbfa1) between the groups were observed (Figures 6(e) and 6(f)).
Osf2/ Cbfa1: A Transcriptional Activator Of Osteoblast Differentiation.
CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia.
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