(redirected from Cellular Retinoic Acid Binding Protein)
CRABICellular Retinoic Acid Binding Protein (endocrinology)
CRABIComputer-Related Addictive Behavior Inventory
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In addition to the nuclear receptors, there exist two cytosolic RA binding proteins, the cellular retinoic acid binding protein I and II (CRABP I & II).
To extend these observations, we quantified the mRNA levels of lacZ and endogenous atRA-target genes, including Crabp2 (cellular retinoic acid binding protein), Ram, and Rarg (Balmer and Blomhoff 2002).
In vitro all-trans retinoic acid (ATRA) sensitivity and cellular retinoic acid binding protein (CRABP) levels in relapse leukemic cells after remission induction by ATRA in acute promyelocytic leukemia.
Physical and functional interactions between cellular retinoic acid binding protein II and the retinoic acid-dependent nuclear complex.
After in vitro and clinical experiences with ATRA over a decade, the following mechanisms involved in development of the drug resistance have been proposed (Figure 4): 1) induction of accelerated metabolism of ATRA; 2) increased expression of cellular retinoic acid binding proteins (CRABPs); 3) constitutive degradation of PML-RAR[alpha]; 4) point mutations in the LBD of RAR[alpha] of PML-RAR[alpha]; 5) P-glycoprotein expression; 6) transcriptional repression by HDAC activity; 7) isoforms of PML-RAR[alpha]; 8) persistent telomerase activity; 9) expression of type II transglutaminase; and 10) topoisomerase II activity.
The cellular retinoic acid binding proteins. J Steroid Biochem Mol Biol 1995;53:459-65.
Transcriptional regulation of the cellular retinoic acid binding protein I gene in F9 teratocarcinoma cells.
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