Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons
from apoptosis induced by oxidative stress.
In this study, we investigated the neuroprotective effects of CGA and its major metabolites in primary cultures of rat cerebellar granule neurons
. We show that CGA and caffeic acid displayed a dramatic protective effect against the nitric oxide donor, sodium nitroprusside.
Ledda et al., "Exposure to 50 Hz electromagnetic radiation promote early maturation and differentiation in newborn rat cerebellar granule neurons
," Journal of Cellular Physiology, vol.
Immunocal provides the essential GSH precursor, cystine, which is transported into cerebellar granule neurons
via the system [x.sub.c.sup.-] antiporter ([Sx.sub.c.sup.-]).
[17.] Gault LM, Siegel RE (1998) NMDA receptor stimulation selectively initiates GABA(A) receptor delta subunit mRNA expression in cultured rat cerebellar granule neurons
. J Neurochem 70: 1907-1915.
Minocycline blocks nitric oxide-induced neurotoxicity by inhibition of p38 MAP kinase in rat cerebellar granule neurons
. Neurosci Lett 2001; 315:61-64.
Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons
. Biochimica et Biophysica Acta 1535(1):78-86,2000.
We evaluated this possibility by using a model of apoptotic death of cultured cerebellar granule neurons
(CGN) induced by potassium deprivation (K5) and staurosporine (Sts).
Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons
. Proceedings of the National Academy of Sciences 94.
Primary murine cerebellar granule neurons
(Skaper et al.
Another study showed that [H.sub.2]S modulated calcium homeostasis in cultured rat cerebellar granule neurons
(CGN) as it induced activation of [Ca.sup.2+] entry through L-type [Ca.sup.2+] channels and thereby of neuronal activity .
Accumulation of BDE-47, as demonstrated in primary rat cerebellar granule neurons
and primary rat neocortical cells (Kodavanti et al.