(redirected from Cervical Intraepithelial Neoplasia Grade 1)
CIN 1Cervical Intraepithelial Neoplasia Grade 1
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The PICOS items were identified (see Appendix 1 in Supplementary Material available online at in this study as follows: P, cervical intraepithelial neoplasia grade 1 (CIN1); I, HPV positivity; C, HPV negative; O, the relative risk (RR) of progression, persistence, and regression of CIN1 in HPV-positive and HPV-negative patients being compared; S, retrospective studies and prospective studies.
Without treatment, cervical intraepithelial neoplasia grade 1 (CIN-1) is more likely to spontaneously regress than it is to progress to cervical cancer.
The proposed Phase II/III trial is planned to be a randomised, double-blind, vehicle-controlled study of Topical Interferon Alpha-2b in patients with cervical intraepithelial neoplasia grade 1 or 2 lesions (CIN 1 or CIN 2 respectively).
TABLE Strategies for managing CIN1 FOLLOW-UP/ INTERVENTION SENSITIVITY FOR REFERRAL RATE AFTER DIAGNOSIS OF CIN1 DETECTING FOR REPEAT AT COLPOSCOPY CIN1 OR HIGHER COLPOSCOPY hr-HPV test at 12 months 92.2% 55% hr-HPV test at 6 months 90.9% 62.4% Cytology at 6 and 12 months 85% 60% Cytology at 6, 12, 18 months 95% Not available hr-HPV test and cytology 94.8% 64.1% at 12 months CIN1, cervical intraepithelial neoplasia grade 1; hr-HPV, high-risk subtypes of human papillomavirus.
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