CRMLN

(redirected from Cholesterol Reference Method Laboratory Network)
AcronymDefinition
CRMLNCholesterol Reference Method Laboratory Network
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[1] Nonstandard abbreviations: CHD, coronary heart disease; NCEP, National Cholesterol Education Program; ATP, Adult Treatment Panel; LSP, Laboratory Standardization Panel; NRS/CHOL, National Reference System for Cholesterol; IDMS, isotope-dilution mass spectrometry; CRMLN, Cholesterol Reference Method Laboratory Network; QC, quality control; UCL, upper control limit; LCL, lower control limit; Sa,, among-run standard deviation; [S.sub.wr] within-run standard deviation; and CAP, College of American Pathologists.
[10] Nonstandard abbreviations: TC, total cholesterol; LDL-C and HDL-C, LDL- and HDL-cholesterol; CHD, coronary heart disease; NCEP, National Cholesterol Education Program; ATP II, Adult Treatment Panel 11; LDL-[C.sub.UC], LDL-C measured by ultracentrifugation; LDL-[C.sub.Fried], LDL-C calculated by the Friedewald equation; TG, triglyceride; LDL-[C.sub.Roche], LDL-C measured by the Roche assay; CRMLN, Cholesterol Reference Method Laboratory Network; PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval; and UC, ultracentrifugation.
For comparison studies, two series (groups A and B) of pooled serum samples were prepared at Osaka Medical Center for Cancer and Cardiovascular Diseases (OMC), an international member of the Cholesterol Reference Method Laboratory Network. Group A (n = 50) and group B (n = 46) samples had a balanced distribution of TC and HDL-C concentrations, respectively, and had triglyceride (TG) values within the reference interval.
Two years ago, the Dutch Lipid Reference Laboratory, a permanent international member of the CDC Cholesterol Reference Method Laboratory Network (2, 3), in collaboration with Roche Diagnostics Nederland B.V.
(6.) Kimberly MM, Leary ET, Cole TG, Waymack PP, for the Cholesterol Reference Method Laboratory Network. Selection, validation, standardization, and performance of a designated comparison method for HDL-cholesterol for use in the Cholesterol Reference Method Laboratory Network.
However, for the purposes of standardization, the CDC's Cholesterol Reference Method Laboratory Network (CRMLN) encourages manufacturers to strive to meet separate accuracy and precision goals.
Evaluation of frozen vs fresh serum samples using the designated comparison method for HDL cholesterol in the Cholesterol Reference Method Laboratory Network [Abstract].
For this purpose, in 1988, the CDC initiated the Cholesterol Reference Method Laboratory Network (CRMLN) to increase standardization support for manufacturers and clinical laboratories.
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