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References in periodicals archive ?
Both NECs and paragangliomas stain for the neuroendocrine markers chromogranin and synaptophysin.
They noted a rather minimal protein expression pattern, with the typical chromogranin and synaptophysin expression in all 4, serotonin expression in 2, and 1 case each expressing glucagon and pancreatic polypeptide.
Markers such as chromogranin, synaptophysin and neuron specific enolase are frequently expressed by neuroendocrine tumors.
PHOX2B can detect undifferentiated NB that lacks classic immunohistochemical markers, such as synaptophysin, chromogranin, and tyrosine hydroxylase.
6,15) While pancreatic NETs and pheochromocytomas/extra-adrenal paragangliomas express chromogranin A and synaptophysin, renal cell carcinomas remain negative for neuroendocrine differentiation marker.
In September 2000, baseline measurements revealed that the patient had elevated serum levels of serotonin (1,120 ng/ml; normal: 55 to 260), chromogranin A (300 ng/ml; normal: 2.
Our experience and that of others showed nearly 100% of P-NETs were positive for both synaptophysin and chromogranin.
Immunohistochemistry will distinguish small cell carcinoma from DLBCL in most cases because small cell carcinoma will usually express pancytokeratin (perinuclear dotlike staining), chromogranin, and synaptophysin and will lack expression of CD45 and CD20.
Immunohistochemical studies showed staining for CD 56, Synaptophysin, Chromogranin, Cytokeratin and Enolase Neuron.
It was not until 1985 that Bussolati et al (5) demonstrated positive chromogranin A staining in these tumors, providing conclusive evidence of hormone production.
The sections were stained for the following markers: Pancytokeratin (Leica Bond AE1/AE3), NSE (Leica Bond 22C9), CD56 (Leica Bond CD564), Vimentin (Leica Bond V9), CD10 (Leica Bond 56C6), progesterone receptor (Leica Bond 16), [beta] catenin (Leica Bond 17C2), chromogranin (VENTANA), synaptophysin (Leica) and CD99 (VENTANA O13).
Chromogranins, including chromogranin A (CgA), are members of the granin family of neuroendocrine secretory proteins located in the secretory vesicles of neurons and endocrine cells.