However, recommendations for palivizumab remain in place for preterm infants younger than 32 weeks' gestational age who have chronic lung disease of prematurity
and needed more than 21% oxygen for at least the first 28 days after birth.
Palivizumab may be administered for seleered infants and children younger than 24 months with chronic lung disease of prematurity
, or a history of prematurity (defined as fewer than 35 weeks" gestation), or .with congenital heart disease.
The FDA's Antiviral Drug Products Advisory Committee voted 14-3 against recommending approval of motavizumab for the indication proposed by its manufacturer, MedImmune LLC., which is the prevention of serious lower respiratory tract disease caused by respiratory syncytial virus (RSV) in children at high risk for RSV disease (premature infants, children with chronic lung disease of prematurity
, and children with hemodynamically significant congenital heart disease).
The analysis included 60 adults, aged 2022 years, from an original cohort of 300 babies with chronic lung disease of prematurity
, and 50 new, age-matched term controls.
It included both infants who were 6 months of age or younger at the time of randomization with a gestational age of 35 weeks or fewer at birth, and children who were 24 months of age or younger with a diagnosis of chronic lung disease of prematurity
requiring treatment within 6 months before the time of randomization.
Montreal -- A diagnosis of chronic lung disease of prematurity
did not predict reduced lung function in childhood in a study of long-term respiratory outcomes in children born extremely prematurely.