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CNLCambridge Neurodynamics Limited
CNLCommission Nationale de Linguistique (French: National Linguistic Commission; Benin & Togo)
CNLSindal Airport, Denmark (IATA code)
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References in periodicals archive ?
These uncommon MPDs include chronic eosinophilic leukemia/hypereosinophilic syndrome (CEL/HES), systemic mastocytosis (SM) with and without eosinophilia, chronic neutrophilic leukemia (CNL), MPN uclassifiable.10
Gotlib J, Maxson JE, George TI and Tyner JW The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment.
A 2013 analysis of exome sequences from 8 aCML cases led to the identification of recurrent SETBP1 somatic mutations; then targeted resequencing demonstrated the SETBP1 mutations were present in 24.3% of 70 patients with aCML, as well as in the closely related disorders unclassified MDS/ MPN (3/30, 10%) and chronic myelomonocytic leukemia (CMML; 3/82, 4%), and in one of four cases of chronic neutrophilic leukemia (CNL) (2).
CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia. Leukemia 2013; 27: 1870-1873, doi: 10.1038/leu.2013.122.
Chronic neutrophilic leukemia 2014: Update on diagnosis, molecular genetics, and management.
The MPN category includes chronic myelogenous leukemia, PV, ET, PMF, chronic neutrophilic leukemia, mastocytosis, and others.
As for the less common MPNs, mutations in the receptor for colony-stimulating factor 3 (CSF3R), initially identified in patients with severe congenital neutropenia, (68-70) have been described in 59% of patients with chronic neutrophilic leukemia or atypical chronic myelogenous leukemia.
The study conducted by researchers at the Knight Cancer Institute at Oregon Health and Science University (OHSU) isolated the molecular mutation that causes chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) in some patients.
The 2008 WHO classification of MPNs has added new entities, including chronic myelogenous leukemia, Philadelphia chromosome-positive (CML); chronic neutrophilic leukemia (CNL); polycythemia vera (PV); primary myelofibrosis (PMF); essential thrombocythemia (ET); chronic eosinophilic leukemia, not otherwise specified (CEL/NOS); mastocytosis; and myeloproliferative neoplasm, unclassifiable (MPN-U).
The differential diagnosis of CML includes granulocytic leukemoid reactions, chronic myelomonocytic leukemia (CMML), chronic neutrophilic leukemia (CNL), and reactive causes of eosinophilia, basophilia, and monocytosis.
Chronic neutrophilic leukemia (CNL) is a rare and fatal myeloproliferative disease, first described by Tuohy in 1920.[30] No more than 70 cases have been reported.
Chronic myelogenous leukemia Chronic myelomonocytic leukemia Mast cell leukemia Chronic monocytic leukemia Chronic neutrophilic leukemia Chronic eosinophilic leukemia
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