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References in periodicals archive ?
s new drug application (NDA) for clobazam oral soluble film (clobazam OSF) for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients two years of age or older, the company said.
Pharmaceutical company Aquestive Therapeutics Inc said on Thursday that it has successfully filed its New Drug Application for clobazam Oral Soluble Film (clobazam OSF) with the the US Food and Drug Administration (FDA) for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS).
To date, there is no specific drug treatment approved by the US Food and Drug Administration (FDA) for catamenial epilepsy though many therapeutic interventions, including hormonal agents (Medroxyprogesterone acetate,10 Clomiphene,11 Triptorelin,12 Leuprolide,13 Progesterone,14-16 Goserelin17), Non-hormonal agents (Acetazolamide,18 Clobazam,8,9 Lamotrigine19) and Neurosteroid-based agents (Ganaxolone20) have been tested with varying degrees of success.
Data from five patients showed an average threefold increase in the level of the active metabolite of clobazam, N-desmethyldobazam, without any change in levels of the drug itself, suggesting that the CBD was interfering with clearance of the metabolite.
8) In placebo-controlled trials in adult patients with partial onset seizures receiving adjunctive levetiracetam, there was no evidence of PK drug interactions between levetiracetam and carbamazepine, clobazam, clonazepam, diazepam, gabapentin, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, primidone, topiramate, valproic acid, vigabatrin, or zonisamide.
Fue estudiada por un grupo multidisciplinario para el manejo integral de la epilepsia, momento en el cual recibia oxcarbazepina (600 mg cada 8 horas), vigabatrim (2 g cada 12 horas) y clobazam (10 mg cada 12 horas) con pobre control de las crisis.
Despues del acto quirurgico, se ingresa la paciente a la Unidad de Terapia Intensiva Pediatrica de la misma institucion, en donde se le mantiene estable y con manejo anticomicial a base de levetiracetam, lacosamida, clobazam y topiramato; a pesar del esquema la paciente quedo con crisis residuales presentadas como nistagmo unidireccional hacia el lado derecho, presentandose con una frecuencia de 4 ocasiones al dia.
This epilepsy syndrome is difficult to control, but seizure management is typically optimized with a combination of antiepileptic medications: valproate, topiramate, clobazam, and ketogenic diet.
Diazepam, alprazolam, clobazam, clonazepam, lorazepam and midazolam have been used through intravenous, oral, intramuscular, buccal, nasal and rectal routes.
Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats.
Clobazam has been used as adjunctive therapy by our center for complex partial seizures associated with sleep.
Antiepileptic therapy was initiated with 5 mg clobazam and subsequent increasing doses over the following weeks.