Javitz et al., "Peripheral complement interactions with amyloid [beta] peptide in Alzheimer's disease: polymorphisms, structure, and function of complement receptor 1
," Alzheimer's & Dementia, 2018.
A human complement receptor 1
polymorphism that reduces Plasmodium falciparum resetting confers protection against severe malaria.
Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene.
Complement receptor 1 and the molecular pathogenesis of malaria.
Human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.
But on the surface of erythrocytes, C4d rises and complement receptor 1 declines with disease activity in SLE.
In one group of 86 patients with active lupus and 32 controls, the mean values for C4 were 24 and 6, respectively and the mean values for complement receptor 1 were 13 and 29.
Regulators of complement activation pathways are soluble (e.g., factor H) or membrane-associated, for example, CD35 (complement receptor 1 (CR1)), CD46 (membrane cofactor protein (MCP)), and CD55 (decay accelerating factor (DAF)).
The membrane regulators complement receptor 1 (CR1), membrane cofactor protein (MCP), and decay-accelerating factor (DAF) regulate complement activation by functioning as cofactors for factor I-mediated cleavage of C3b and C4b (in the case of CR1 and MCP) or by accelerating the decay of C3 convertase and C5 convertase (in the case of CR1 and DAF).
A team of researchers now reports the identity of this protein as the complement receptor 1
(CR1), also known to help protect red cells from attack by the immune system.
TP10 is a soluble form of complement receptor 1
, a naturally occurring protein found on blood cells.
Das, "Reduced complement receptor 1
(CR1, CD35) transcription in systemic lupus erythematosus," Molecular Immunology, vol.