Degradation of catecholamines occurs either through O-methylation by COMT
or by de-amination with the help of monoamine oxidase (MAO).
Nonetheless they noted that given that aspirin was preventively prescribed to millions of individuals and the COMT
genetic variant was extremely common, this study underscores the potential importance of individualizing therapies based on genetic profiles.
Among people with a moderate pain perception, the COMT
and OPRK variants were 25 percent and 19 percent more often found than in those with a high pain perception.
Various studies have found evidence indicating that polymorphism in both the 5-HTT gene and the COMT
gene are linked with differences in the Big Five Personality traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism and Openness).
Se conoce al polimorfismo funcional Val158Met en el gen COMT
como un marcador susceptible para diversos tipos de enfermedades materno perinatales, entre ellas la RCIU (16).
Newborns with a variant of COMT
also had reduced volume in the temporal cortex, a brain characteristic that turns up in people with schizophrenia.
The study is the first to show the combined effects of the COMT
gene with adolescence cannabis use and how this can impact on the later development of schizophrenia.
is an unpasteurised, cream-colour hard cheese unique to the area.
gene comes in two versions, known as Val158 and Met158.
They are missing one copy of COMT
because of a deletion in a tiny section of one of the two copies of chromosome 22, where COMT
and other genes reside.
Of those participants, four had a weak COMT
variant and had excessive amounts of dopamine in their brains.
MAOB (monoamine oxidase type B) inhibitors reduce the breakdown of dopamine in the brain and COMT
(catechol-O-methyltransferase) inhibitors reduce the brain's ability to breakdown levodopa.