CpG island methylator phenotype
in colorectal cancer.
Issa, "CpG island methylator phenotype
in colorectal cancer," Proceedings of the National Academy of Sciences of the United States of America, vol.
Diefes et al., "Identification of a CpG island methylator phenotype
that defines a distinct subgroup of glioma," Cancer Cell, vol.
Iacopetta, "CpG island methylator phenotype
is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer," Clinical Cancer Research, vol.
CRC: Colorectal Carcinoma; CIN: Chromosome Instability; MSI: Microsatellite Instability; CIMP: CpG Island Methylator Phenotype
; FAP: Familial Adenomatous Polyposis, HNPCC: Hereditary Nonpolyposis Colorectal Cancer; APC: Adenomatous Polyposis Coli; MMR: Mismatch Repair; ACF: Aberrant Crypt Foci
Diet and lifestyle factor associations with CpG island methylator phenotype
and BRAF mutations in colon cancer.
Xu et al., "Prognostic and predictive value of CpG island methylator phenotype
in patients with locally advanced nonmetastatic sporadic colorectal cancer," Gastroenterology Research and Practice, vol.
The subset of colorectal cancers with exceptionally high frequency of CpG island methylation were referred to as CpG island methylator phenotype
(CIMP)  and showed distinct clinicopathological characteristics [3-5].
As we previously have observed (12), markers were hypermethylated in a common subset of CRC samples(88% of CRC samples with a PMR of >10% for any marker) and showed a typical CpG island methylator phenotype
As indicated earlier, 3 main molecular genomic and epigenomic pathways have been identified in CRC and precancerous lesions: microsatellite instability secondary to deficient DNA mismatch repair, CpG island methylator phenotype
potentially resulting in transcriptional silencing of hypermethylated genes, and chromosomal instability.
These lesions often harbor BRAF mutations and exhibit CpG island methylator phenotype
features, which are not seen in adenomatous polyps, the more common precursor for colorectal cancer.
In his article, Gyeong Hoon Kang, MD, addresses the following topics: (1) 4 molecular subtypes of colorectal cancer exist, which can be defined by the combination of CpG island methylator phenotype
and microsatellite instability (MSI) status, with their own clinicopathologic features and precursor lesions; and (2) a geographic difference exists in MSI rate and BRAF mutation rate of colorectal cancers.