CuZnSODCopper-Zinc Superoxide Dismutase (enzyme)
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(a) In the hippocampus of mice treated with SCO in the presence or absence of APN, protein levels of antioxidant enzymes such as HO-1, MnSOD, and CuZnSOD were determined by Western blot analysis.
Lee, "Enhanced tolerance to methyl viologen-induced oxidative stress and high temperature in transgenic potato plants overexpressing the CuZnSOD, APX and NDPK2 genes," Physiologia Plantarum, vol.
They found that MEL induced synthesis of new protein as a condition for regulation of gene expression of all the three antioxidative enzymes, CuZnSOD, MnSOD and GSH-Px.
Ho et al., "Overexpression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury," Free Radical Biology and Medicine, vol.
[H.sub.2][O.sub.2] is produced by the enzymes superoxide dismutase (isoforms CuZnSOD and MnSOD), which are localized in the muscle sarcolemma and mitochondria (Jackson et al., 2007).
Induction of nNOS/iNOS by methamphetamine or MDMA (Figure 3) constitutes part of the mechanism of methamphetamine damage, as selective inhibition or genetic inactivation of nNOS and overexpression of cupper zinc superoxide dismutase (CuZnSOD), an enzyme that catalyzes the dismutation of superoxide into oxygen and hydrogen peroxide, prevent methamphetamine neurotoxicity [23, 37, 38].
In mitochondria, superoxide anion ([O.sub.2.sup.-]) can be dismutated to hydrogen peroxide ([H.sub.2][O.sub.2]) by two enzymes, namely, copper-zinc superoxide dismutase (CuZnSOD) and manganese superoxide dismutase (MnSOD), that are present in the mitochondrial matrix and in the intermembrane space, respectively [65].
Blood samples were taken by venipuncture before and at the end of spa therapy as well as on the 5th day for the assay of Copper-Zinc superoxide dismutase (CuZnSOD) and catalase (CAT) activity.
Zinc and copper are components of CuZn-Superoxide Dismutase (CuZnSOD), an important antioxidant enzyme.
A CuZnSOD esta presente principalmente no citoplasma e em algumas organelas denominadas peroxissomas (BOWIER & CAPRO, 2002; KINNULA & CAPRO, 2003).