A novel minor histocompatibility antigen recognized by HLA-A31 restricted cytotoxic T lymphocytes
generated from HLA-identical bone marrow donor lymphocytes.
There are data on the possibility of the involvement of the DNase activity of T-lymphocytes not only in the DNA fragmentation induced by cytotoxic T lymphocytes
(CTL) to target cells, but also in the process of programmed death of type 1 of these cytotoxic cells (CTL).
For some time it has been widely believed that a kind of T cell called cytotoxic T lymphocyte
(CTL) is particularly important in controlling HIV.
"A low number of donor-specific cytotoxic T lymphocytes
identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.
Cytotoxic T lymphocyte
antigen-4 (CTLA-4, CD152) blocks the production of IL-2, the expression of IL-2R, and the cell cycle of activated T lymphocytes .
The product is a 'prime-boost' cancer immunotherapy product aimed to synergistically induce and expand in vivo cytotoxic T lymphocytes
targeting NY-ESO-1 - found in a broad set of tumours.
Yamanaka, "Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes
in human leukocyte antigen-A24 + glioma patients," Oncology Reports, vol.
Primary induction of human CD8+ cytotoxic T lymphocytes
and interferon-gamma-producing T cells after smallpox vaccination.
These are CD4 cell factors that are necessary to turn on the CD8 cells (cytotoxic T lymphocytes
Virologists have long known that cells called cytotoxic T lymphocytes
(CTLs) battle viruses by latching onto an infected cell and delivering the kiss of death-an outburst of compounds that destroys both the cell and its infectious cargo.
According to Galena Biopharma, the nelipepimut-S sequence stimulates specific CD8+ cytotoxic T lymphocytes
(CTLs) after binding to HLA-A2/A3 molecules on antigen presenting cells and the activated specific CTLs recognise, neutralise and destroy, through cell lysis, HER2 expressing cancer cells, including occult cancer cells and micrometastatic foci.
In antitumor immunity, cytotoxic T lymphocytes
(CTL) and natural killer (NK) cells play a role as effectors, which kill tumor cells .