, bye-bye red pee, hello hair again.
The death in the current study was likely "related to the severe immune suppression imposed by the use of Cytoxan
prior to the rituximab," senior author Dr.
A small study provides a further clue that a chemotherapy drug--cyclophosphamide (Cytoxan
)--may stabilize some very active forms of MS that haven't responded to standard treatments.
Now, because of the Adriamycin and Cytoxan
she's been given, the patient must take Emend, Aloxi, and Decadron (for nausea), Neulasta and Aranesp (to boost her blood cell counts), and Prilosec and Mylanta (for reflux).
Approximately 3 weeks later, she began a high dose chemotherapy regimen with intravenous etoposide phosphate and cytoxan
, and intra-arterial carboplatin with osmotic blood brain barrier disruption (BBBD).
Chemotherapy drugs called alkylating agents, which include cytoxan
and nitrogen mustard, carry the highest risk of infertility.
P List (a) U List (b) Epinephrine (adrenaline) P042 Chlorambucil (Leukeran) U035 Nicotine P075 Cyclophosphamide (Cytoxan
, Neosar, Procytox) U058 Nitroglycerine P081 Daunomycin (Dauorubicin, Cerubidine) U059 Physostigmine P204 Diethylstilbestrol U089 Physostigmine salicylate P188 Melphalan (Alkeran) U150 Warfarin > 0.3% P001 Mitomycin C (Mutamycin) U010 Paraldehyde U182 Phenacetin U187 Reserpine U200 Saccharin U202 Selenium sulfide U205 (e.g., dandruff shampoos) Streptozocin (Zanosar) U206 Uracil mustard U237 Warfarin (Coumadin) < 0.3% U248 (a) Representative P-listed drugs (some have other uses).
Immunosuppressives, such as azathioprine (Imuran) and cyclophosphamide (Cytoxan
), restrain the overactive immune system by blocking the production of some immune cells and curbing the action of others.
The three drugs given intravenously were Cytoxan
, Oncovin, and Adriamycin.
"This was the first opportunity to provide a substitute for Cytoxan
," Russillo says.
With chemotherapy such as cytoxan
(2 g/[m.sup.2]) and paclitaxel (175 mg/[m.sup.2]) with G-CSF at 10 [micro]g/kg as priming (13), most patients have recovery of counts and an adequate circulating progenitor mass to begin collection by approximately the 10th day after chemotherapy.
* Anti-cancer drugs cyclophosphamide ( Cytoxan
), tamoxifen (Nolvadex), paclitaxel (Taxol) and etoposide (Toposar, Etopophos, VePesid).