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DFENDepartament de Física i Enginyeria Nuclear (Catalan: Department of Physics and Nuclear Engineering)
DFENDOT (Digital Opportunities Task) Force Entrepreneurial Network (Group of Eight)
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Sibutramine: a novel anti-obesity drug: a review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine. Int J Obes Relat Metab Disord 1998; 22:18-28.
"Our unique genetic mouse models have revealed that POMC neurons are physiologically important targets of potent anorexigenic 5-HT compounds such as d-fenfluramine to suppress appetite," said Elmquist.
Much recent work has documented the safety and efficacy of appetite suppressants in weight control.[7-46] Appetite suppressants that have been studied and found to be safe, effective, and of low abuse potential include diethylpropion hydrochloride (75 mg daily), mazindol (1 mg daily), phentermine hydrochloride, fenfluramine hydrochloride (d-fenfluramine and the racemic dl-fenfluramine), fluoxetine hydrochloride (60 to 80 mg daily), and phenylpropanolamine hydrochloride (75 mg daily, available over the counter)[7-46] (Table).