D-NAMENG-D-Nitro-Arginine Methyl Ester
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We have shown that D-NAME has inductive properties that are suppressed by SNAP, indicating that application of D-NAME also leads to a decrease in NO.
Email: brandhor@sfu.ca Abbreviations: D-NAME, D-nitroarginine-methyl-ester; GA, geldanamycin; GBD, geldanamycin binding domain; HSP90, heat shock protein 90; L-NAME, L-nitroarginine-methyl-ester; NO, nitric oxide; NOS, nitric oxide synthase; ODQ, IH-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; RD, radicicol; sGC, soluble guanyl cyclase; SNAP, S-nitroso-N-acetylpenicillamine.
Long-term administration of D-NAME induces hemodynamic and structural changes in the cardiovascular system.