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DAAOD-Amino Acid Oxidase (enzyme)
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D-serine is preferentially degraded through oxidation by the enzyme D-amino acid oxidase [27] and also by the serine racemase-mediated water [alpha]-elimination induced by elevated intracellular D-serine levels [26] (Figure 1).
After P21, both D-serine and serine racemase are reduced in glial cells at the vestibular nuclei, and high content of D-serine switches from glial cells to neuronal cell bodies and dendrites mostly because of an increased expression of glial D-amino acid oxidase at mature stages [29].
CPC can be transformed by two-step enzymatic method by D-amino acid oxidase (DAAO) and glutaryl acylase (GAC) or One-step enzymatic method by a CPC acylase (CA) (1,2,5,7,8).
The conversion of D-Met to L-Met is not a limiting factor due to the existence of substantial D-amino acid oxidase activity in different tissues, such as kidney, liver, stomach, duodenum, jejunum and ileum, of pigs (Fang et al., 2010).
Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mu-tant mice lacking D-amino acid oxidase activity.
The 21 studies of this fourth volume include discussions of the disruption of alanine racemase gene of Schizosaccharomyces pombe, D-amino acid oxidase activity assays, the transformation of plants with D-amino acid resistance selectable markers, the resonance Raman study of charge-transfer complexes on porcine D-amine acid oxidase, and enzymes acting on D-amino acid amides.
Preclinical studies have combined D-serine with an inhibitor of D-amino acid oxidase to prevent D-serine breakdown.23 In rodents, this approach produces a 30-fold increase in d-serine potency.
The purification of D-Amino acid oxidase has been described by using Sephadex G75 [5].
Laboratory experiments indicated that G72 produces a protein that interacts with the enzyme D-amino acid oxidase (DAAO).
L-Homocystine and D-amino acid oxidase were from Sigma.
Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801.
A second group is the D-amino acid oxidases, which also use flavins as cofactors but use D-amino acids as substrates.