137) For example, these biomarkers, along with histologic evaluation, are helpful in identifying dysplastic lesions from inflammatory reactive changes and in distinguishing low- and high-grade dysplasia as well as DALM
lesions and sporadic tubular adenoma.
There is unanimous agreement in the literature that the detection of HGD or of a DALM
with any degree of dysplasia carries a sufficiently high risk of concurrent CRC or short-term progression to CRC to warrant immediate colectomy barring unusual clinical circumstances.
Adenomas and adenoma-like DALMs
in chronic ulcerative colitis: a clinical, pathological, and molecular review.
It has been shown that adenoma-like DALMs
can be treated with simple polypectomy followed by surveillance.