DAPK1Death-Associated Protein Kinase 1
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Methylation specific PCR (MSP) was used to determine methylation of p15, p16, p73, APC, DAPK1 and hMLH1.
Promoter methylation of DAPK1, RAR-[sz] and MGMT in exfoliated cervical cytology and its clinical application (in Chinese).
We found that IFN-[gamma]-induced autophagy was defective in Indo~'~ macrophages and not modified by DAPK1 inhibition [22].
The promoter methylation statuses of DAPK1, MGMT, and RARB were positively correlated with the cervical disease grades, respectively.
Similar results have been previously reported using digital MS-HRM for the DAPK1 gene in chronic lymphocytic leukemia patients (7).
Researchers hypothesized that by preventing DAPK1 from binding with the NMDA receptors, they could prevent the calcium overloads and cell deaths.
As shown in Tables 1 and 2, both stimulants caused regulatory effects on multiple targets: IL-1[beta] caused an upregulation of CTSS and DNA damage-regulated autophagy modulator 1 (DRAM1) as well as a downregulation of B-cell lymphoma 2 (BCL2); autophagy-related gene 3 (ATG3), tumor necrosis factor receptor superfamily, member 6 (FAS); transmembrane protein 74 (TMEM74); death-associated protein kinase 1 (DAPK1); eukaryotic translation initiation factor 4 gamma (ESR1); CXC motif, receptor 4 (CXCR4); and immunity-related GTPase family M (IRGM).
published a study in 2013 [35] that suggests that this might be due to increased DAPK1 expression.
Quantitative studies on the methylation status of RASSF1, MLH1, DAPK1,andMGMT tumor suppressor genes demonstrated that their promoter regions were commonly methylated.
In particular, miR-129 has 16 predicted target genes [platelet-derived growth factor receptor, alpha polypeptide (PDGFRA); platelet-derived growth factor receptor, beta polypeptide (PDGFRB); epidermal growth factor receptor (EGFR); phospholipase C, gamma 1 (PLCG1), SHC (Src homology 2 domain containing) transforming protein 4 (SHC4); protein kinase C, alpha (PRKCA); protein kinase C, beta (PRKCB); protein kinase C, delta (PRKCD) protein kinase C, epsilon (PRKCE); protein kinase C, iota (PRKCI); growth factor receptor-bound protein 2 (GRB2); son of sevenless homolog 1 (SOS1); SOS2; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS); death-associated protein kinase 1 (DAPK1); DAPK2; DAPK3; and ribosomal protein S6 kinase, 90kDa, polypeptide 5 (RPS6KA5) (also known as MSK1)].
Promoter methylation of DAPK1, E-cadherin and thrombospondin-1 in de novo and therapy-related myeloid neoplasms.