En el presente estudio, se analizaron los polimorfismos mas comunes de los genes DAT1
, SERT, COMT y BDNF con el objetivo de determinar su posible asociacion con el TDAH en un contexto familiar en una muestra de la poblacion de Bogota.
Moraga et al., "Genotypic interaction between DRD4 and DAT1
loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families," American Journal of Medical Genetics--Neuropsychiatric Genetics, vol.
Association of the dopamine transporter (DAT1
) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample.
Their study focused on the dopamine transporter gene DAT1
, which can influence leadership and is important for reward and motivation systems in humans.
Association between harmful alcohol consumption behavior and dopamine transporter (DAT1
) gene polymorphisms in a male Finnish population.
Association study between the DAT1
, DBH and DRD2 genes and cocaine dependence in a Spanish sample.
According to the study, the three genes that have been identified are - DAT1
, DRD2 and DRD4 - which have been linked to behaviors such as attention regulation, motivation, violence, cognitive skills and intelligence.
Using the above described rationale, Beaver and colleagues (2008) found that a strong positive association between numbers of sex partners and antisocial behavior and polymorphisms of the DA transporter gene (DAT1
) explained variation in both number of sexual partners and in criminal conduct for males.
Bunlardan en fazla uzerinde durulan ve olumlu bulgularin elde edildigi genler DRD4 ve DAT1
(32) In a prospective longitudinal study of 305 subjects from birth to age 15, it was confirmed that children homozygous for the 10-repeat allele of the common dopamine transporter (DAT1
) polymorphism, who were also exposed to prenatal tobacco smoke, had much higher hyperactivity-impulsivity than children without this combination of environmental and genetic risk factors.