DATATOPDeprenyl and Tocopherol Antioxidative Therapy of Parkinsonism
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Carter et al., "Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort," Neurology, vol.
(10.) Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa.
However, in the DATATOP study, it did not affect the probability that the patient would need levodopa.[28] Apomorphine, an injectable dopamine agonist, is under investigation as a treatment for late levodopa failure.
This conclusion came from a carefully conducted study supported by the NINDS called DATATOP (Deprenyl and Tocopherol Antioxidative Therapy for Parkinson's Disease) that examined, over 5 years, the effects of both deprenyl (selegiline) and vitamin F, on early Parkinson's disease.
Fahn et al., "Freezing of gait in PD: prospective assessment in the DATATOP cohort," Neurology, vol.
Scientists at Massachusetts General Hospital and the Harvard School of Public Health and including physicians at the University of Rochester Medical Center, led the study, which was based on a landmark study known as DATATOP, which was conducted two decades ago.
Primarily the findings have come from analysing biological samples, mainly blood and cerebrospinal fluid, collected from people with Parkinson disease who participated the DATATOP study.
It is not yet clear whether deprenyl alone has subtle symptomatic effects that might explain the results of the DATATOP study, or whether deprenyl has actual neuroprotective properties.