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Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines.
After DC-SIGN expression, the epithelial cells gain the abilities of secreting inflammatory factors, presenting antigens, activating T-cells, and initiating inflammatory reactions.
Studies into endocytosis via DC-SIGN observed MHC class II mediated antigen presentation , although more recent studies showed that DC-SIGN targeted cargo can also be cross-presented to CD8 T-cells .
West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.
15] However, the possible role of DC-SIGN and DC-SIGNRs in vertical transmission of HIV is still poorly understood.
The normal role of DC-SIGN is to capture pathogens so that fragments of those pathogens can be presented as antigens on the surface of the dendritic cells.
Variants of CC chemokine receptor--CCR2, Monocyte chemoattractant protein-1 (MCP-1) and stromal cell derived factor-1[alpha] (SDF-1[alpha]) and DC-SIGN genes have been shown to be associated with susceptibility or resistance to HIV-1 manifestations and disease progression (3,6-8).
Keywords: HIV-1; Myeloid and plasmacytoid dendritic cells; IFN-[alpha]; Toll-like receptor; DC-SIGN receptor.
The Dutch investigators unearthed DC-SIGN while studying how dendritic cells adhere to T cells in order to activate them.
sup] The mannan receptor DC-SIGN was found to recognize several pathogenic fungi, including C.
The Nottingham work has focused on the role of DC-SIGN, a receptor found on the surface of antigen presenting cells.
SARS-CoV may also bind to cells through the alternative receptors DC-SIGN or L-SIGN (20,21), but the binding sites for these alternative receptors have not been defined.
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