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DC-SIGNDendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Non-Integrin (protein)
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15] However, the possible role of DC-SIGN and DC-SIGNRs in vertical transmission of HIV is still poorly understood.
020) and DC-SIGN (median values in HIV-positive cases, 26.
The normal role of DC-SIGN is to capture pathogens so that fragments of those pathogens can be presented as antigens on the surface of the dendritic cells.
While it has been known for some time that dengue used DC-SIGN to attach to cells, Liu and her colleagues used high-resolution microscopy to study exactly how the viruses used the protein to gain entry into cells.
Variants of CC chemokine receptor--CCR2, Monocyte chemoattractant protein-1 (MCP-1) and stromal cell derived factor-1[alpha] (SDF-1[alpha]) and DC-SIGN genes have been shown to be associated with susceptibility or resistance to HIV-1 manifestations and disease progression (3,6-8).
Genotyping of CCR2, MCP-1, SDF-la and DC-SIGN exon4 repeat polymorphisms: Genomic DNA was isolated from peripheral blood mononuclear cells and granulocytes obtained from the blood of patients and healthy controls using salting out procedure (18).
Figdor's team has developed effective inhibitors, including monoclonal antibodies, of both DC-SIGN and L-SIGN.
We are excited to be working collaboratively with Alexion to commercialize antibodies to DC-SIGN and L-SIGN for the treatment of various immune disorders and to increase our understanding of dendritic cell biology through a research and discovery collaboration", commented Dr.
The Dutch investigators unearthed DC-SIGN while studying how dendritic cells adhere to T cells in order to activate them.
The Nottingham work has focused on the role of DC-SIGN, a receptor found on the surface of antigen presenting cells.
Expression of DC-SIGN and DC-SIGNR in placentas of HIV-positive patients.
L-SIGN and DC-SIGN are also expressed in placental tissue, and thus the findings may also explain why HCV is readily passed from mothers to their newborn children.