DCQADistributed Continuous Quality Assurance
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Multiple reaction monitoring (MRM) using the precursor to product ion pairs for quantification of scutellarin, DCQA, and rutin (IS) was m/z 463 [right arrow] 287, 517 [right arrow] 163, and 611 [right arrow] 303.
Likewise, they observed large inter-individual variation in the pharmacokinetic profile of all DCQA compounds.
h Male 2.7 [+ or -] 1.3 2.2 [+ or -] 0.4 Female 5.6 [+ or -] 6.4 1.7 [+ or -] 0.2 Note: [C.sub.max]: peak plasma concentration, AUC: area under the plasma concentration-time curve, V: volume of distribution, CL: systemic clearance, K: elimination rate constant, [t.sub.1/2]: terminal phase half-life, DCQA: dicaffeoylquinic acid, *: P < 0.05 between male and female, P < 0.001 between male and female.
Plasma concentrations of scutellarin and DCQAs were used for pharmacokinetic data analysis with Phoenix software (Pharsight Corp, Mountain View, CA, USA).
For scutellarin, there were significance gender differences on the peak plasma concentrations ([C.sub.max]) (P < 0.05) and on the area under the plasma concentration-time curve (AUC, [AUC.sub.0[right arrow]1h] x [AUC.sub.0[right arrow]5h], [AUC.sub.0[right arrow][infinity]] (P < 0.001); while for DCQAs, there was no significant gender difference (P > 0.05) in values of [C.sub.max] or AUC, by two sample t-test.