DFDUDesert Flight Duty Uniform (US Air Force)
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Gemcitabine and dFdU concentrations in the tumour cells were also found to be high enough to allow radiosensitization.4
Gemcitabine and its metabolite, dFdU both are radiosensitizers that easily cross the BBB and reach high concentrations within tumour cells.
Interestingly, 2',2'-difluorodeoxyuridine (dFdU), the major inactive metabolite of gemcitabine, is a substrate of ABC transporter [27].