DFF40CAD/DNA (Caspase-Activated Deoxyribonuclease/Deoxyribonucleic Acid) Fragmentation Factor 40
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Upon cleavage, DFF45 releases and activates the endonuclease DFF40, which breaks DNA strands in the internucleosomal regions, producing fragments of various lengths; these fragments form a unique laddering pattern.
The cleavage of DFF45 inactivates its inhibitory function on DFF40 and causes nuclear DNA degradation by DFF40, leading to cell death (Zhang et al.
Out of the complex DFF40 and DFF45 (DNA fragmentation factor 45), the caspase-3 cleaves DFF45 and as a result of that, DFF45 dissociates from DFF40, causing oligomerization of DFF40 which has DNase activity.