The structure we found was totally unexpected and really opens the door for us and others to design a new class of inhibitors targeting DHPS
that will help us avoid side effects and other problems associated with sulfa drugs," said Stephen White, Ph.
Investigations for DHPS
mutations were carried at specific 55th and 57th codon using PCR-RFLP (restriction fragment length polymorphism) assay.
Although the precise relation between mutations in the DHFR and DHPS
genes in clinical sulphadoxine-pyremethamine resistance is unclear, current data show that the presence of a sensitive DHFR allele is highly predictive of sulphadoxine-pyremethamine treatment success irrespective of the DHPS
fighters Nils von Blottnitz and Philipp Beddies were on the competition mat for the first time.
Caption: 48 DHPS
pupils on their way to bi-annual Sport Olympia 2014 in Johannesburg
normally combines the molecules DHPP and pABA during part of a biochemical pathway that produces folate, a nutrient these bacteria need to survive.
Two grade 10 senior secondary students of DHPS
, Yana Haenisch and Almut Voigts, have successfully participated in Trustco's Miss Teenager Namibia Starperformer Competition.
Several investigators have reported an association between failure of prophylaxis when using sulfa drugs and substitutions of 2 aa within the putative sulfa binding site of DHPS
at positions 55 (Thr to Ala, mutation Ml) and 57 (Pro to Ser, M2) (1-4).
Eighty four learners completed their final 12th year at DHPS
The locus of dihydropteroate synthase (DHPS
) is also of interest because DHPS
is the target of sulfonamides, the main drugs used to treat Pneumocystis pneumonia (PCP).
This Saturday evening 23 June, they will sing at the DHPS
The Bronze Lilly award went to Eberhard Werner from Delta and Doreen Engberts from DHPS
, while the Silver award went to Urte Remmert from Namib High School.