DLPFCDorsolateral Prefrontal Cortex
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Stimulation studies have targeted a brain area called the dorsolateral prefrontal cortex (DLPFC), which appears to play a role in the "conscious regulation of food craving and consumption of calorie-dense foods."
[34], three pairs of ROIs (left and right DLPFC, left and right entorhinal cortex, and left and right thalamus) were manually outlined from a T1-weighted MRI scan acquired from a dataset of 82 subjects (42 diagnosed with schizophrenia plus 40 HC).
Of course, explaining to a managed care company that you're having a positive effect on reprocessing information in a person's DLPFC is not going to get you paid as quickly as changing medications or dosages.
Several evidences have demonstrated that state-dependent changes and metabolic in the left DLPFC of MDD can be reversed by rTMS.[17] From an electrophysiological point of view, 5-HT2A receptors in the hippocampus might be influenced via pyramidal neurons by the stimulation of the DLPFC.
In a more recent study that involved participants presenting with mild vascular dementia, four consecutive day sessions of anodal tDCS (for a 20-minute period using 2 mA) on the left DLPFC generated positive additional effects on visual short-term memory, verbal working memory, and executive control [23].
A decrease in functional connectivity using fMRI was reported in the left putamen, SMA, and DLPFC in PD patients compared to NCs [13].
In a substance-naive sample of 12- to 14-year-olds, Wetherill and colleagues (2012) examined functional connectivity in working-memory--relevant brain regions, including the bilateral dorsolateral prefrontal cortex (DLPFC) and the posterior parietal cortex (PPC).
After stimulation of the dorsolateral prefrontal cortex (DLPFC), young women experience increased cravings for high-calorie snacks and eat more of those foods when given the opportunity, according to the study by researchers at University of Waterloo, Ont., Canada.
The most used target to treat depression with rTMS consists of high-frequency stimulation of the left dorsolateral prefrontal cortex (DLPFC) (8).
The two regions were the dorsolateral prefrontal cortex (dlPFC), which sits behind the temples, and the ventromedial prefrontal cortex (vmPFC), which is in the middle of the forehead just above the eyes.
Another study found a reduction in bilateral dorsolateral prefrontal cortex (DLPFC) and left amygdala, and an increase in the left occipital cortex and right temporal cortex in manic subjects with psychosis.
The area of the brain that is important for many executive functions, such as context representation, information processing, and working memory, is the dorsolateral prefrontal cortex (DLPFC).