Let-7g-5p HMGA2  miR-10b-5p Bcl6  miR-19a Undetected  miR-19b Smad7  miR-21 FasL, PDCD4 [41, 42] miR-22-3p HDAC6  miR-23a Fas, Runx2 [70, 71] miR-24 Tcf-1  miR-27 APC  miR-29a-3p DKK1, Kremen2, sFRP2  miR-30 family Smad1, Runx2, LRP6  miR-100 BMPR2  miR-124 Dlx5, Dlx3
, Dlx2  NFATc1, RhoA, Rac1  miR-125 ErbB2  miR-140-5p BMP2  miR-142 APC  miR-148a Kdm6b  MAFB  miR-2861 HDAC5  Table 3: miRNA dysregulated in plasma of osteoporotic patients and their function.
Dlx2 and Dlx3
are expressed during tooth morphogenesis and have been shown to play a key role during cell differentiation and apoptosis.
Hue, "Expression and localization of DLX3
, PPARG and SP1 in bovine trophoblast during binucleated cell differentiation," Placenta, vol.
(2011) reported that a SNP in DLX3
gene at 24 Mb of SSC12 was associated with drip loss in the same population as in this study, while a QTL for drip loss was detected at 28 Mb of SSC12 (Table 3).
Distinct roles for distal-less genes Dlx3
and Dlx5 in regulating ectodermal development in Xenopus.
Asada, "Association of DLX3
gene polymorphism and dental caries susceptibility in Japanese children," Archives of Oral Biolog, vol.
Roscigno et al., "A dominant mutation etiologic for human tricho-dento-osseous syndrome impairs the ability of DLX3
to downregulate ANp63a," Journal of Cellular Physiology, vol.