7, 12 dimethylbenz (a) anthracene (DMBA
) is among those PAH compounds and known to cause tumor formation in various tissues in both human and animals.
procera root in DMBA
induced genotoxicity in Wistar rats by micronucleus assay.
Abbreviations AlphaLISA: Amplified luminescent proximity homogeneous assay DMBA
: 7,12-Dimethylbenzanthracene ENO1: Enolase 1 ERCP: Endoscopic retrograde cholangiopancreatography EUS FNA: Endoscopic ultrasonography-guided fine-needle aspiration IHC: Immunohistochemical MBP-1: c-myc promoter binding protein 1 PanIN: Pancreatic intraepithelial neoplasia PBS: Phosphate-buffered saline PC: Pancreatic cancer PDAC: Pancreatic ductal adenocarcinoma.
Pretreatment with eugenol has also been observed to impede DMBA
croton oil inducing the skin carcinogenesis in mice by greatly reducing the transcription and translation level of two oncogenes, cMyc and H-ras.
The majority of in vivo studies performed to elucidate the role of melatonin in estrogen-responsive breast cancer have used as a model that chemically induced dimethylbenz(a)anthracene (DMBA
) or N-methyl-N-nitrosourea mammary (NMU) carcinoma in young rats.
(41) On the other hand, the chemopreventive effect of eugenol on DNA damage induced by 7,12 dimethylbenzanthracene (DMBA
) has been evaluated in MCF-7 cells.
The shocking revelation came after Indian shot-putter Manpreet Kaur was provisionally suspended after being tested positive for banned stimulant DMBA
A number of methods have been reported for the synthesis of 3,4-dihydropyrano[c]chromenes with the catalysts such as pyridine , [K.sub.2]C[O.sub.3], diammonium hydrogenphosphate , MgO , TBAB , Si[O.sub.2]PrS[O.sub.3]H , 4-(dimethylamino)pyridine (DMAP) , trisodium citrate , ammonium acetate , polymer supported sulphanilic acid , basic ionic liquid , CuO nanoparticles , p-dodecylbenzenesulfonic acid , amberlyst A21, silica-grafted ionic liquid  Ti[O.sub.2] , thiourea dioxide , [Fe.sub.3][O.sub.4]@SiO2-imid-PMAn nanoparticles , and A,A-dimethylbenzylamine (DMBA
)  have also been reported to promote this reaction.
Another animal model induces pancreatic cancer through the implantation of dimethylbenzanthracene (DMBA
) in the pancreas.
Conversely, PPAR[gamma] haploinsufficiency  or expression of a dominant-negative Pax8-PPAR[gamma] transgene  and direct or indirect inhibition of PPAR[gamma] [21, 25] enhance DMBA
Contrary to K14E7, the K14E6 mice are more prone to develop spontaneously malign tumours in the skin of 1-year-old mice, or in 6-month-old mice after 5 months of DMBA
+ TPA treatment.
The decrease of MDA in the RSV-treated groups was similar with the previous report that MDA increased in 7,12-dimethylbenz(a)anthracene (DMBA
) group but decreased in DMBA
group treated with RSV (DMBA
+ R) .