was able to describe interferon gamma responses to 51 DosR regulon-encoded proteins in LTBI positive, human immunodeficiency virus- (HIV-) negative adult household contacts of APTB cases from The Gambia, Uganda, and South Africa.
The T cells induced by these DosR proteins may provide help to B cells and promote antibody responses.
Recombinant DosR regulon-encoded proteins, Rv1733c, Rv0081, Rv1735c, and Rv1737c, and CFP-10/ESAT-6 fusion protein were kindly provided by Professor Tom H.
Factors Associated with Concentrations of IgG Antibodies to DosR Proteins and CFP-10/ESAT-6.
Los genes Rv2626c, Rv2625c y Rv2624c del patogeno humano Mycobacterium tuberculosis pertenecen al regulon de persistencia o dosR, y su expresion se incrementa de manera significativa en diferentes condiciones asociadas a persistencia.
Os genes Rv2626c, Rv2625c e Rv2624c do patogeno humano Mycobacterium tuberculosis pertencem ao regulon de persistencia ou DosR (DevR regulon), e sua expressao se incrementa de maneira significativa em diferentes condicoes associadas a persistencia.
tuberculosis belong to the dosR regulon, which is induced during in vitro persistence-related conditions, and like most of the genes that constitute this regulon, their functions are unknown.
DosR is a transcriptional factor required for induction of the dormancy regulon genes.
(28) Given the necessary conditions for the dormancy state induction, the DosR regulon is activated through the action of two histidine kinase sensors, DosT (Rv2027c) and DosS (Rv3132c).
Thus, the induction of the DosR regulon must be triggered prior to complete hypoxia, allowing adaptation and survival mechanisms to be transcribed and translated right before ordinary energy sources are depleted.
(34) Besides, as stated by Mehra et al., (35) the activation of the DosR prevents the immune system to establish a proper T helper 1-type of response against the pathogen.
This factor acts on macrophages, enhancing the production of IL-1[beta], TNF-[alpha], and reactive oxygen species, indirectly contributing, to DosR regulon's activation, as a mechanism of mycobacterial growth arrest.