DPPIV


Also found in: Medical.
AcronymDefinition
DPPIVDipeptidyl Peptidase IV
References in periodicals archive ?
DPPIV is responsible for gelatin binding and ECM degradation in adhesion hotspots.
of H bonds (kcal/mol) energy (Kcal/mol) DPPIV -6.15 -6.36 2 PTP-1 -6.35 -6.51 3 IR -5.91 -6.10 1 PPAR -7.68 -7.81 2 [gamma] Receptors H bond H bond Ref.
Docking results obtained for each ligand with the receptors were analyzed apart from docking energy, and binding modes and interaction of each ligand with the functional residues of IR (PDB ID: 1IR3), AR (PDB ID: 1USO), PTP1B (PDB ID: 2F70), and DPPIV (PDB ID: 3F8S) were analyzed in detail by visually inspecting the docked complexes using MVD.
This article focuses on recent developments in the management of type 2 diabetes; specifically, the legacy effect and macrovascular disease, glycaemic targets and macrovascular disease, glycaemic management (specifically focusing on initiation of insulin therapy and the group of agents shortly to be introduced in South Africa, the incretins and DPPIV inhibitors) and the role of self-monitoring of blood glucose (SMBG).
Incretin mimetics and DPPIV inhibitors in the treatment of type 2 diabetes mellitus.
For example, some regulatory peptides are metabolized/ modulated by membrane-bound peptidases such as dipeptidyl peptidase IV (DPPIV or CD26) and angiotensin-converting enzyme (22-25).
won the Best Poster award, presented by Reed Business Information Scientific Group, for his presentation, Crystal Structure of DPPIV: A Type II Diabetes Target.
DppIV is a serine protease that cleaves GM-CSF, a potent cytokine that activates macrophages and neutrophils to kill fungi [41].
Considering the previously demonstrated antiapoptotic, anti-inflammatory, and antioxidative potential of DPPIV inhibitor in renal injury experiments [2-4], we supposed that gemigliptin may have a renoprotective effect in a murine model of adriamycin-induced nephropathy.
However, DPP IV is widely expressed also in the glomeruli [61]and an increase of DPPIV activity in podocytes is correlated with kidney injury [62, 63].