DPPOSDiabetes Prevention Program Outcomes Study
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Key clinical point: On long-term follow-up, there appear to be no cognitive differences among the treatment arms of the DPPOS.
Major finding: At year 8 of follow-up, cognition was similar among participants in the lifestyle and metformin arms of DPPOS.
Data source: A total of 2,331 cognitive assessments in the lifestyle and metformin arms of DPPOS.
Factors associated with increased diabetes risk in DPPOS included age younger than 45 years (HR, 1.
26) in DPPOS independent of previous treatment," the investigators also noted, adding that this was "probably because of the high rate of weight regain in DPPOS with associated adverse effects on diabetes risk.