The D[LSUB.CO] was significantly lower in subjects with both DPTB and PPTB.
HRCT fibrosis scores in DPTB, but not PPTB, were significantly higher than in NPTB, being 0.36% (95% CI 0.06-0.65; p=0.017) higher on multivariate analysis, but overall scores were low (Tables 4 and 5).
The mean gas trapping score on expiration was higher in both the DPTB (38.9%) and PPTB groups (32.8%) compared with the NPTB group (26.7%; p=0.006).
However, the WT4 in the RUL in DPTB and PPTB subjects combined was higher than in NPTB subjects (median 0.80 mm; (interquartile range (IQR) 0.6 1.1) v.
Fortuitously, the proportions of subjects in the three groups were similar, and the fact that the intermediate group (PPTB) showed features similar to the DPTB group for most endpoints supports the conclusions of the study.