Following the publication of the DRCR
.net study demonstrating that laser therapy was superior to IVTA, a phase 2b clinical trial of a triamcinolone sustained delivery intravitreal implant (I-vation, Surmodics, Inc., MN, USA) was terminated.
Recently, the DRCR
.net found that IVTA had best effect on VA improvement within 4 months of the application and that this effect was transient (39).
Beck RW, Edwards AR, Aiello LP, Bressler NM, Ferris F, Glassman AR,Diabetic Retinopathy Clinical Research Network (DRCR
The competitive advantage was showed by the Private Cost Ratio (PCR) and the Domestic Resource Cost Ratio (DRCR
net study, (7) the OCT results generally paralleled the visual acuity results, with a greater beneficial effect seen at the 4-month visit in the 4-mg IVTA group compared to 1-mg group, no difference between the 2 groups during the second year.
Recently, a new, large, randomized DRCR
.net study investigated the efficacy of intravitreal TA in combination with laser photocoagulation in comparison with intravitreal ranibizumab with prompt or deferred laser photocoagulation or laser photocoagulation alone.
The Diabetic Retinopathy Clinical Research Network (DRCR
.net) conducted a study with a more complicated design.
In Appendix A of this 1989 paper, which sets out the methodology of the study, DRCR
and DRCR* correspond, respectively, to the concepts referred to in this paper as DRC(P) and MDRC.
The Ranibizumab Plus Prompt Or Deferred Laser Or Triamcinolone Plus Prompt Laser For Diabetic Macular Edema (DRCR
.net Protocol I Study) indicated that nonetheless ranibizumab plus deferred laser reached best VA results; it is significant to note that ranibizumab plus prompt laser-treated eyes reached a similar 5-year VA with lower number of injections needed (median: 17 versus.