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DRD2Dopamine D2 Receptor Gene
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'DRD2 has emerged as a viable novel target in neuro-oncology and controls diverse signaling pathways.
Abbreviations DNA - deoxyribonucleic acid DRD2 - dopamine receptor D2 SNP - single nucleotide polymorphism cAMP - cyclic adenosine monophosphate GDP - guanosine diphosphate GTP - guanosine triphosphate qPCR - real-time polymerase chain reaction Ct - cycle threshold Studies conducted in vivo, using positron emission tomography (PET), showed significant individual variations in terms of the density of DRD2 receptors in human striatum.
Weiss et al., "Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations," Human Molecular Genetics, vol.
In a previous study, the analgesic effects produced by rTMS applied to S1 were demonstrated in subjects that presented the DRD2 957TT genotype [114].
"Interestingly, for the first time, we also found that the activation in a part of the brain called the striatum was increased when those with the variant in FTO looked at high-calorie foods, but this depended on which variant of the other gene DRD2 they possessed.
Assessment of association between the dopamine D2 receptor (DRD2) polymorphism and neurodevelopment of children exposed to lead.
For instance, the dopaminergic receptor genes DRDla and DRD2 were differentially expressed 2 days after reperfusion after stroke in mice (Sieber et al., 2014).
Specific ABCB1 variants and DRD2 genetic polymorphisms (simultaneous occurrence of [greater than or equal to] 2 genetically determined phenotypes) might determine the dosage requirements of methadone.
An epistasis effect of functional variants on the BDNF and DRD2 genes modulates gray matter volume of the anterior cingulate cortex in healthy humans.
A newer supplement for brain healing is the natural product Synaptamine, developed by Ken Blum, who has been a noted researcher and coined the phrase reward deficiency syndrome to describe the impulsive and compulsive disorders and personality disorders associated with a decrease in dopamine (DRD2) receptors in the brain.
Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia and are consistent with leading pathophysiological hypotheses.