promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.
BRCA2 interacts with the histone acetylase P/CAF (Scully and Livingston, 2000) BRCA2-associated factor BRAF35 and DSS1
. The sites of the eight BRC repeats, six of which interact with Rad51, the oligonucleotide binding (OB) domain that interacts with single-stranded DNA and the carboxyterminal NLS (nuclear localization signal) are indicated.
En la Figura 7 se observa que hasta el gateway la transferencia multimedia y la senalizacion se realizan a traves de MTP, ISUP y DSS1
, protocolos y elementos propios de la RTPBC.
In mouse skin cells treated with phorbol ester tumor promoters, Dss1
was expressed during early stages of tumor formation.