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Vaccinations with DTwP vaccine and for other diseases are provided in all primary health care centers (public institutions) and some private institutions certified for vaccination.
These two strains have been used for production of DTwP vaccine in Iran.
In observational studies, Tdap effectiveness was 66%-72% among adolescents who largely received DTwP for some of the childhood doses (5,6).
According to the current vaccination schedule in Poland, infants receive the first three doses of DTwP in the first 6-8 weeks of life every 6-8 weeks, the 4th dose in the 16th-18th month of life, and a DTaP booster at 6 years of age.
For both the DTaP and DTwP vaccines, combination vaccines are available that include inactivated polio virus (IPV), Haemophilus influenza B (Hib), and hepatitis B (Hep B) (WHO, 2005).
It previously was reported that seizures and/or hypotonic-hyporesponsive episodes occurred after 1 of every 1750 DTwP immunizations and that acute encephalopathy occurred in 0 to 10.5 cases per one million doses of DTwP vaccine.
Rebecca Hoskins, from Shilbottle, Northumberland, claims the additive known as thiomersal, which is contained in diphtheria, tetanus and whooping cough vaccine (DTwP), is the most likely cause of her daughter Kaia's condition.
Waning immunity after experiencing pertussis infection, after receiving the old DTwP vaccine that was discontinued in the United States years ago because of safety issues, and after receiving the newer DTaP and Tdap vaccines, has been known to occur for many years.
For example, in this study, VE for patients 10-16 years of age who received the DTwP vaccine under the accelerated schedule would increase from 82% to 90% if coverage increased from 97.7% to 98.7%.
In fact, immunity against pertussis wanes, and DTwP (whole-cell pertussis) and DTaP vaccines don't last forever, which is part of the reason we're seeing these outbreaks.
(1-5) Vaccines combining inactivated whole-cell Bordetella pertussis antigens with diphtheria and tetanus toxoids (DTwP) have been used for over 60 years and have been central to the World Health Organization (WHO) Expanded Program of Immunization (EPI) since 1974.
(19) All licensed DTaP vaccines were less likely to elicit common reactions than diphtheria-tetanus-whole-cell pertussis (DTwP) vaccines.
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