DZNDeutsches Zahnarzt Netz (German)
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Therefore, the present study was undertaken to evaluate the possible protective effects of CAP on oxidative stress and antioxidant status after 7 weeks' exposure to a sublethal dose of DZN in rats.
DZN-treated group: DZN (Sigma-Aldrich, Germany) at a dose of 10 mg/kg/d in corn oil was given through gavage.
For DZN activity, we transferred 10 [micro]L diluted serum to a microplate.
We measured the initial rate of substrate hydrolysis from the maximum of the slope (A/min) over a 10-reading interval with extinction coefficients of 1310, 3000, or 17 000 L x [mol.sup.-1] x [cm.sup.-1] for the AE, DZN, and PXN assays, respectively.
The protective doses of safranal or crocin against DZN effects were similar or less than our previous experiments in which these agents showed pharmacological activities such as hypnotic and anxiolytic (Hosseinzadeh and Noraei 2009), aphrodisiac (Hosseinzadeh et al.
RESULTS: In the liver, DZN elicited global sensitization, characterized by parallel up-regulation of AC activity itself and of the responses to stimulants acting at [beta]-adrenergic receptors, glucagon receptors, or G-proteins.
RESULTS: In PC12 cells, after 48 hr of exposure, CPF, CPF oxon, and DZN enhanced gene expression for AChE-R by about 20%, whereas CPF and DZN, but not CPF oxon, increased AChE-S expression by 20-40%.