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DAPKDeath-Associated Protein Kinase
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Feigelson et al., "Tumor suppressor death-associated protein kinase attenuates inflammatory responses in the lung," American Journal of Respiratory Cell and Molecular Biology, vol.
[4] Genes: E6, E6 transforming protein [human papillomavirus 18]; E2, E2 regulatory protein [human papillomavirus]; E7, E7 transforming protein [human papillomavirus]; TP53, tumor protein p53; IFNG, interferon, gamma; TMC6 (previously known as EVER1), transmembrane channel-like 6; TMC8 (previously known as EVER2), transmembrane channel-like 8; DAPK, death-associated protein kinase 1; CDH1, cadherin 1, type 1, E-cadherin (epithelial); RASSF1, Ras association (RalGDS/AF-6) domain family member 1; CDKN2A, cyclin-dependent kinase inhibitor 2A; FHIT, fragile histidine triad; MGMT, O-6-methylguanine-DNA methyltransferase; RARB, retinoic acid receptor, beta.
Striving to prevent such calcium overloads, the research team discovered that an enzyme, DAPK1 (Death-Associated Protein Kinase 1), binds to a portion of the NMDA receptor and acts as a "cell death signal" during strokes.