This pleural injury is caused by a severe delayed-type hypersensitivity reaction
in response to the rupture into the pleural space of a sub pleural focus of M.
Allergic reactions to latex consist of immediate-type hypersensitivity reaction and delayed-type hypersensitivity reaction
. The latter is a cell-mediated immune reaction in the skin that usually results from a hypersensitivity to one of the numerous chemicals added during processing (von Hintzenstern et al.
 Mast cells have received little attention in leprosy, but evidence linking them with delayed-type hypersensitivity reactions
raises the possibility that they may be of some importance in leprosy, in both the nonreactional and reactional states.
Eosinophil recruitment into sites of delayed-type hypersensitivity reactions
in mice, Journal of Leukocyte Biology, 69: 353-360.
Pregnancy, obesity and long duration of current heparin treatment were associated with a delayed-type hypersensitivity reactions
Mild cutaneous, delayed-type hypersensitivity reactions
to the vaccine were extremely common.
On an individual patient basis, there is a relatively low risk of true IgE-mediated type-1 hypersensitivity reactions--those that typically occur within minutes of exposure to the allergen and can potentially progress to anaphylaxis--as well as the more benign delayed-type hypersensitivity reactions
. In medical settings, however, because vaccines are so widely administered, this is a "relatively common clinical problem," according to the authors.