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Related to Desmoplakin: desmoplakin II
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References in periodicals archive ?
Probands with TGF/3-3 gene mutation presented only non sustained ventricular tachycardia/ arrhythmias while probands carrying the mutation in the either desmoplakin or plakophilin-2 genes presented with all the four types--sustained ventricular tachycardia, non sustained VT (NVST), polymorphic ventricular complexes (PVCs) and ventricular fibrillation.
Paraneoplastik pemfigusta saptanmis olan antijenler plakin protein ailesinden olan desmoplakin 1 ve 2, envoplakin, periplakin, plektin ve 230-kDa bulloz pemfigoid antijeni ve 170 kD agirliginda bilinmeyen bir proteindir (2,8,32).
What probably happens first is association of things like envoplakin and involucrin to the site of the desmosome by cross-linking - more specifically, to the tail of desmoplakin, which extends 100 nm from the main plaque of the desmosome into the cytoplasm.
Breaking the connection: Displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly.
Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/beta-catenin signaling pathway in human lung cancer.
Two hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type specific intermediate filaments.
The structure of the carboxy-terminal domain is dominated by six highly homologous repeats that also occur in lesser number in desmoplakin (3 repeats; Green et al.
43,28) In EMT, activated Akt causes E-cadherin repression and cellular changes, such as loss of cell adhesion and loss of apico-basolateral cell polarization, as well as changes in the subcellular distribution of proteins such as internalization of desmoplakin and induction of mesenchymal markers, such as vimentin.
2, CK5+8, CK7, 34[Beta]E12, Leu-5, CK18, CK19, CK20, CK22, desmoplakin, desmin, myoglobin, estrogen and progesterone receptors, p53, Ki-67, and HER-2 protein were performed using the avidin-biotin complex technique.
In addition, actin, epithelial membrane antigen, CD68, S100 protein, and desmoplakin have been reported to be expressed in some FDC sarcomas.