In this current study, the efficacy and safety of the DETP by injury location during short-term treatment of pain associated with minor sports injuries or inflammatory pathologies was evaluated based on the results from five clinical studies.
In this current study, the results from five clinical trials were integrated into a database to examine the safety and efficacy of the DETP by injury location.
Fisher's exact test was used to compare the frequencies of AEs between the DETP and placebo treatments.
This pooled analysis dataset consisted of 1,165 patients and there were no statistically significant differences between patients treated with the DETP or for the placebo group in any category of injury location, according to age or gender (Table 1).
In NHANES, the concentrations for the 75th percentile for all Mexican Americans were as follows: DEP, 26.6; DETP
, 4.9; and diethyldithiophosphate, 1.7 nmol/L.
Furthermore, the stratified analysis by spraying season showed higher slopes for DETP ([beta] = 0.0043; p = 0.0001) and DEP ([beta] = 0.00053; p = 0.0001) and higher relative risks for DEP (2.59) and DETP (1.68) for sex null during the spraying season (Table 4).
Although DMTP was the metabolite excreted in higher proportion, DEP and DETP showed the strongest association with sex null, suggesting the need for further studies regarding their potential sex null aneuploidogenic properties.
Alkylphosphates [dimethylphosphate (DMP), dimethylthiophosphate (DMTP), dimethyl-dithiophosphate (DMDTP), diethylphosphate (DEP), diethylthiophosphate (DETP), diethyldithiophosphate (DEDTP)] are urinary metabolites of many phosphoric esters, and are derived by A-esterase-catalyzed hydrolysis (14).
Alkyl- Mean % Detection phosphate recovery(a) CV1%(b) limits(c) ([micro]g/L) DMTP Na 85.8 9.1 2 DMDTP K 90.0 11.9 2 DETP K 99.2 8.8 2 DEDTP K 101.0 9.8 2 DMP K 100.0 11.4 3 DEP K 87.9 7.9 3
The influence of these variables was evaluated for single alkylphosphates and for the sum of dimethyl (DMP + DMTP + DMDTP), diethyl (DEP + DETP + DEDTP), and all metabolites expressed in nanomole per gram creatinine.
The % pos was approximately 95% for these two metabolites, 75% for DEP, and 48 and 12% for DETP and DEDTP, respectively.